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Recently I did a radio interview with longtime friend Al Korelin and blurted out that anyone who actively followed the gold/silver markets and did not appreciate how manipulated they are, was a moron. Not sure how that went over with Al?s listening audience, but I would like to parlay that comment here to deal with its significance.
You truly have to be mentally challenged if you follow the gold/silver market action and cannot appreciate something is very amiss, as per the confused Mitsui gold people, as brought to your attention the other day. There is NOTHING to be confused about. The more bullish the news for gold, the more reasons for the price to soar and the more The Gold Cartel deviants go into action to suppress both the gold and silver prices. How many times does the GATA camp have to point this out before the dingbats at Mitsui, and the rest of the mainstream gold world, will go there? The answer is infinity. These mainstream establishment gold pundits will NEVER tell their people the truth about what the gold market is all about. Hara-kiri would be their first choice before telling the truth.
Most people naturally think the Mayans got it wrong about the world ending on December 21. Of course it is that way at first glance, but if what takes place in the economic/financial market arenas in the years ahead that I see coming, it might prove them correct in a way not commonly thought of (just a few years off and in a different articulation). Whatever is done with our fiscal cliff issue, it represents how incapable our politicians are of dealing with our mounting fiscal deficits and debt in America. It will not signify the end of the world, but could very well come to represent a moment when it becomes CLEAR our standard of living is going to significantly deteriorate ? and an end to a standard of living as we Americans have known it ... the end of that world. If the Mayans are correct in that regard, which I believe to be the case, the standard of living of most Americans, and others around the world, is going to change dramatically for the worse.
As this all kicks in, the realization of how broke the US is, along with many other nations, will take center stage. The understanding of the US money printing game will command the same attention on that stage. The dollar will begin its tapioca swan dive. Gold and silver will begin launches to doubling their prices for starters. The Gold Cartel will have to go into a retreat mode like we have not seen yet.
The Gold Cartel knows what is coming as presented above, which is why they have bombed gold and silver the past month+ when the fundamentals registered the most bullish factoids imaginable. PRICE ACTION MAKES MARKET COMMENTARY. The clueless (or disingenuous) out there in the mainstream gold world refuse to explain why the price of gold has behaved so counterintuitively ?, but the GATA camp will, and does, all the time.
Now, this is what I really want to get to ? in what I truly believe could be of meaningful support during this time of the investing public RUNNING AWAY FROM THE GOLD/SILVER/SHARE MARKETS, just when the focus should be on them the most! The bullish sentiment is really that bad.
To get right to the point, and to try and be of assistance, this is what I have done well at in the past ? getting into a major market move when few investors are paying attention to incredibly bullish fundamentals. That said, I am among THE WORLD?S WORST at dealing with market tops and taking profits. But, since we are dealing with major corrections in gold and silver, accompanied by dreadful bullish sentiment, that should not be of most concern at the moment.
SO, it is my opinion the prices of gold and silver are going to go into an EPIC move up stage, especially silver, next year. Silver will make all-time highs and be streaking for $100 an ounce. If there ever was a time to skew your investment portfolio towards silver, and pay extra attention, it is right now!
It is just human nature to NOT get it at market bottoms, or after significant corrections like we have just had, and to think out of the box. I was fortunate to have learned about all of this from three truly legendary financial market figures, and now there is a fourth. All of them understood true supply/demand numbers which were not appreciated by the investment world at the time. Each could spot a big picture trade and act on their knowledge way ahead of the pack. They were the smart ones, not me. I knew they knew what they were talking about with successful investment backgrounds to prove it. I listened to everything they had to say and learned from them what to spot and why, and then go with them.
I realize many veteran Caf? members know some of this and of those whom I am referring to, but it is worth repeating, right now, and focusing on just where we are after the recent Gold Cartel waterfall attacks. Each of these big picture thinkers could spot markets out of sync and knew how to take advantage of them and play for big money. They have been my mentors and are extraordinary individuals (what I cumulatively learned from them all those years I am hoping is indirectly passed on your way) ?.
*Daniel L. Ritchie
?
Daniel L. Ritchie became chairman and CEO of the Denver Center for the Performing Arts, one of the nation?s largest cultural complexes, in January 2007. He is the immediate past chairman of the Daniels Fund board, and is president of the Temple Hoyne Buell Foundation, which focuses on early childhood education and development.
Dan was chairman of the board of the University of Denver from 2005 to 2007, where he served as the university's sixteenth chancellor from 1989 until 2005. During his tenure, the DU pioneered the teaching of ethics at both the graduate and undergraduate levels. Chancellor Ritchie collaborated with Bill Daniels to incorporate ethics, values, and social responsibility throughout the business school curriculum. The business school was renamed Daniels College of Business in 1994 in honor of Bill Daniels.
In June 1994, Dan announced a personal gift to the university of $15 million, achieved through sale of some 19,600 acres of his Colorado ranch. Since then, he has given the university the remainder of the ranch, and its sale has netted more than $50 million for various projects?
I met Dan at the New York Athletic Club in the mid 1970?s. We were in the gym lifting weights and he asked me about a pork belly quote, like in the Daily News, which was not there. What a nice man, I thought, and after taking a futures market class at the Cornell School of Hotel Administration, I thought why not go after what this seemingly bright man told me. I called my Merrill Lynch broker and bought a pork belly contract with a $500 margin requirement at the time. The first day after my broker put on my trade, I lost half my money. What a mistake I thought. Pork bellies went LIMIT UP the next nine out of ten days! I was hooked to go into the commodity futures industry. I asked Dan what I should do after a $4500 gain on a $500 investment in two weeks. I will never forget what he said, "Bill, you have done pretty well for your first trade, take those profits," which I did in a nanosecond. If I only had done that for the rest of my investment career!
Dan was very tied into the astute Refco operation out of Memphis, and made a fortune trading the cattle, hog and pork belly markets, with some great soybean trades thrown in there too.
?
I will never forget talking to Dan over a dinner when he was pondering whether to resign from Westinghouse Broadcasting, after being the number two guy under Lew Wasserman at MCA pictures, to run D.K. Ludvig?s empire. Ludvig was the richest man in the world at the time. And I will never forget that we flipped a coin to determine who would pay for dinner that night.
Education: Master of Business Administration, Harvard University; Bachelor of Arts / Science, Long Island University
Marital Status: Married
Children: 4
***
?
Ray is obviously a genius. Now famed CEO Sandy Weill didn?t think so when he fired Ray from his hedging director position at Shearson Hayden Stone in the mid 1970?s. Mr. Weill did not appreciate that, to make a hedging point, Ray brought in a girl with a fur coat on during a presentation of his in San Francisco. Her naked body was all that was left when Ray asked her to take off the coat.
So Ray started Bridgewater Associates. I had just joined Shearson and he needed someone to do a lot of grunt work for him. Many a night I took the subway from downtown Manhattan to midtown around 11:00. Ray got me going financially back then with his buy corn and feeder cattle futures and sell cattle futures when their margins were too fat. We did the reverse when they were too unprofitable. Made 100% on my money in days to weeks every time.
I know a number of you have seen this picture of Ray and me in Rio way back when, but it is too much fun to pass up here.
?
*Frank Veneroso
I was recruited to join the ill-fated Drexel Burnham on Park Avenue in 1980. That is where I met Frank as he was interested in buying bond futures when the interest rates were running up to 20%. He was early and took some hits, but then sold THE HIGH TICK after their first mega rally. I know, I did the trade. He made a killing.
Frank was known as a Wall Street Whiz Kid back then who was making money every year during the DOW dog days. He was then a consultant to a number of governments. One of my favorite financial stories ever is this one:
The Stock Market
Recollections of the Greatest Market Bubble Ever?
Memories of the Souk al Manakh
How large can a bubble grow before it bursts? Farther than you think. And there need not be a fatal pinprick that makes it burst. And when it bursts, the crash that ensues can be deeper and more discontinuous than you could ever imagine?
Frank was commissioned by the World Bank to do a study on the copper market in 1986. Copper was nowhere back then, the price depressed to around 46 cents a pound. Frank was stunned to learn how bullish the fundamentals were because of the obvious demand which would be surfacing from Asia. FEW realized what was about to transpire, preferring to concentrate on the increasing importance of fiber optics. We muddled with the copper futures trade for a year. Then in May of 1987 there were no deliveries on the May contract. That was it I thought, the KEY to getting the trade right. I bought thousands of out of the money copper options. Copper went to $1.46 per pound by the end of the year, surviving the 1987 stock market crash in October of that year. I made $27 million on the trade and then found a way to blow a good deal of it. But, being Jackie Onassis? neighbor in Bernardsville, N.J. for a couple of years is still a fond memory.
***
All of that brings me to where we are today and the reason I would like to make a commotion out of this commentary?
*Eric Sprott
Eric, who is one of GATA?s most ardent supporters, is one of the nicest guys you will ever meet and a true genius. As my good friend John Embry (brilliant in his own right) has told me for years, Eric is the best student of supply/demand dynamics he has ever come across. His presentation at the Dos Passos Table is just one example of what John is referring to.
Eric has been jumping up and down about the price of silver?s potential for many years now and was very visible at certain conferences not that long ago when the price was $14/16 an ounce. He has been all over the place this year talking to investors about what he thinks the price of silver is going to do and why. Eric has publicly stated silver is going to $100 per ounce and higher. He is my anchor when I pound the table about silver ? that same anchor of formidable insight I learned so long ago from the likes of Dan Ritchie, Ray Dalio, and Frank Veneroso. It is not me you need to pay attention to, but Eric!
I don?t need to be able to break down the supply/demand numbers like Eric has done; and like Dan, Ray and Frank have done for so many years. I know they know what they are talking about. What I can bring to the table is an appreciation of just how much gold and silver have been manipulated, and orchestrated down to artificially low prices, which will not stand in the years ahead. JP Morgan, and others suppressing the price, has to be close to being forced into backing off. Their use of derivatives to suppress the price in the face of an extremely tight physical market ought to be very close to having run its course. Knowing what we know in the GATA camp about what JP Morgan has done will prove to be invaluable in the months and years ahead. No one knows that more than Eric.
The investment opportunity of a lifetime is staring us in the face and not that many investors out there get it. Eric does and he has backed it up publicly with his investments: his ETF (PHYS) is an example. Fortunes will be made in silver over the years ahead for those willing to do their homework and take a plunge ? and that will be most true in the silver shares whose firms have the goods in the ground.
Investing in many of the junior/exploration stocks in the gold/silver sector has been a horror show these last years. While I have been so right about gold and silver for the past 12 years, my second biggest investment mistake ever was not to take profits around 2008 with my share selections when the legendary Bob Bishop told the attendees at GATA Goes To Washington conference in April of 2008 that the move up in the gold/silver shares was over for the time being. As you may know, Bob is going to let his latest thoughts known at GATA?s fundraiser in Vancouver on January 21 at the Pan Pacific Hotel following the Cambridge House conference.
BUT, as bad as the junior/exploration sector has been in recent years, it will be that good by double or triple, or much more, in the years ahead. Think NEWTON?S LAW!
Silver is on its way next year to $100 per ounce. You want to bet against Eric Sprott? And that is the reason for this special commentary. Ritchie, Dalio, and Veneroso are true legends in the futures trading arena, and in the making big money in the markets arena. So is Eric. Keep that in mind and spread the word.
While the standard of living in America and other places is likely to deteriorate significantly in the years ahead, those who have stayed with various gold/silver investments ought to be happy campers. Should that Mayan prediction be all about a drastic change in our standard of living as we have known it (the end of that world), owning silver and the silver shares in the years ahead will be a counter to some darker times on the horizon.
(Phys.org)?As 2012 comes to a close, scientists and engineers are looking forward to molding the future, starting with the work they do in their own labs. Phys.org has interviewed a few of today's leading researchers in the areas of energy and lighting, and asked them what they're most excited about in their fields in the years to come.
Dr. David Faiman, Director of Israel's National Solar Energy Center and Chairman of the Department of Solar Energy & Environmental Physics at Ben-Gurion University of the Negev, specializes in the large-scale provision of electric power from solar energy.
Professor Nadarajah Narendran, Director of Research at the Lighting Research Center at Rensselaer Polytechnic Institute, specializes in optics, optoelectronics, and lighting. His main area of research is solid-state lighting.
Phys.org: To reflect on the past, in your opinion, what has been the most exciting part of your field over the past 10-15 years or so ? especially if this is something that most people would not have predicted to be exciting 10-15 years ago?
Narendran: Semiconductor light sources displacing traditional incandescent and gas discharge light sources in lighting applications.
Faiman: First, that concentrator photovoltaics is capable of being cost-competitive with fossil fuel, in sunny parts of the world. Second, that solar and wind power could be as "cheap" as hospitals, schools and roads, if they were all paid for with our taxes.
Phys.org: What do you predict will be one or some of the most exciting discoveries or advances in your field in the next 10-15 years?
Narendran: Solid-state light sources catering to the dynamic lighting needs of people with very little energy use.
Faiman: I don't make predictions. But the most important area for research is electrical storage ? in order to enable the intermittent output from solar and wind generators to be readily available for the needs of the electricity grid.
Phys.org: Where do you see personal electronics going in the next 10-20 years? What kinds of devices might we have, and how will we interact with them?
Narendran: Personal electronics (like smart phones) interacting and controlling appliances within and remote from the space one occupies.
Phys.org: Which alternative energy generation technology (such as solar, concentrated solar, wind, geothermal, etc.) do you think will grow the most in the next 10 or 20 years? Why?
Faiman: I don't make predictions. Generally, they all need to grow. In fact, their respective growth rates will depend upon the whim of politicians, followed by VCs.
Phys.org: Do you think one of these alternative energy technologies will eventually become dominant to the same extent that oil, coal, and gas are now? Why or why not?
Faiman: Probably, ONLY if the oil, coal, gas industry lets it happen, or if some powerful and independent government (e.g., that of China) makes it happen.
Phys.org: Do you think we will ever become independent of oil, coal, and/or gas? Why or why not?
Faiman: Technically we could. But whether we will depends on a host of political considerations.
Phys.org: Twenty years from now, will most of our cars still be fueled by gasoline? If you think "yes," what about in 50 years? What will be the most difficult part in making this transition?
Faiman: I prefer to focus on what could happen: (1) Electric cars are an exciting potential for the near term, which, as has been amply demonstrated, is a practical possibility; (2) For the longer term, we need to develop liquid hydrogen as an alternative for hydrocarbon fuels. To this end, there are two fundamental scientific problems that must be solved: a physics problem (how to prevent the tiny hydrogen molecules from percolating out through the walls of their containment tank), and a chemistry problem (how to reduce the extreme flammability of this element).
Phys.org: If you don't mind really speculating, what do you think the world will look like 100 years from now, or more? Your thoughts may be influenced by your field of expertise, or may be more generally influenced by your life overall.
Narendran: Lighting playing a much greater role in our daily life, completely changing the way we implement lighting within our built environments and how we light our spaces with LEDs and OLEDs, and people realizing their value.
Faiman: One hundred years ago, there were two World Wars ahead of us. If we can prevent one more during the next 100 years, Dayenu!
From my field of expertise: it would be nice if our great grandchildren would find it hard to believe that electricity was once generated by burning stuff that they dug out of the ground.
From another part of my life: It would also be nice if the music and reputation of Giacomo Meyerbeer could be restored to where Berlioz, Bizet and Saint Saens placed them, viz, on a par with "Beethoven, Leonardo and Raphael" (Bizet), and not in the pit in which Wagner, Schumann and Mendelssohn ["That jew banker who happens to write music" (Wagner)] successfully buried them during the 20th century.
Copyright 2012 Phys.org
All rights reserved. This material may not be published, broadcast, rewritten or redistributed in whole or part without the express written permission of Phys.org.
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BANGKOK (AP) ? Asian stock markets rose Friday, hours before President Barack Obama and key lawmakers were to meet at the White House to try to hammer out an 11th-hour budget compromise to avert the so-called fiscal cliff. Wall Street also appeared set for a session of gains.
Lawmakers have until Monday night to reach a deal before hundreds of billions of dollars in automatic tax increases and deep cuts to government spending kick in. Such a drastic reshuffling of money could throw the U.S. into another recession, economists have warned.
However, failure to avoid the fiscal cliff doesn't necessarily mean tax increases and spending cuts would become permanent, since the new Congress could pass legislation canceling them retroactively after it begins its work next year.
Ahead of the opening bell, Dow Jones industrial futures were marginally higher at 13,005. S&P 500 futures gained nearly 0.1 percent to 1,411.80. European shares were mixed in early trading. Britain's FTSE 100 rose 0.1 percent to 5,959.89. Germany's DAX was nearly flat at 7,653.34. France's CAC-40 shed 0.1 percent to 3.670.03.
The day's market strength was in Asia. Japan's Nikkei 225 index rose 0.7 percent to 10,395.18, its highest level since March 10, 2011, the day that a mammoth earthquake and tsunami pummeled Japan's northeastern cost. Export shares posted big gains as the country's currency continued to recoil against the dollar. Mazda Motor Corp. jumped 4.8 percent and Isuzu Motors Ltd. surged 4.5 percent.
Investors have been cheering newly named Japanese Prime Minister Shinzo Abe and his calls for more public works spending to reinvigorate the economy. He also wants the Bank of Japan to raise its inflation target from 1 to 2 percent to drag the country out of two decades of deflation, or steadily declining prices that have deadened economic activity.
But Francis Lun, managing director of Lyncean Holdings in Hong Kong, said he was skeptical that the new prime minister's roadmap would prove effective in the long run.
"He will increase the deficit, print more money and try to spend out of the recession. If you print or borrow money, you give the economy a sense of false hope," he said. "It's like taking opium. You feel good but eventually you have to come down."
Hong Kong's Hang Seng rose 0.2 percent to 22,666.59, while South Korea's Kospi added 0.5 percent to 1,997.05. Australia's S&P/ASX 200 gained 0.5 percent to 4,671.30.
"The fiscal cliff seems to have lost its negative influence on global markets," said Lun. "Even if it falls into the fiscal cliff, you will only reduce the deficit by about $100 billion. In Chinese terms, it's like trying to douse a fire with a cup of water. They should do what Europe has done and try to impose austerity."
Markets got some lift from optimistic data out of the U.S. on Thursday and a statement from the German finance minister, Wolfgang Schaeuble, who said in an interview that the worst of the debt crisis in the 17 European Union countries that use the euro appears to be over.
In the U.S., the average number of people seeking unemployment benefits over the past month fell to the lowest level since March 2008, a sign that the job market is healing.
Benchmark oil for February delivery rose 24 cents to $91.11 in electronic trading on the New York Mercantile Exchange. The contract fell 11 cents to finish at $90.87 per barrel.
In currencies, the euro fell to $1.3180 from $1.3240 late Thursday in New York. The dollar gained to 86.12 yen from 86.02 yen.
___
Follow Pamela Sampson on Twitter at http://twitter.com/pamelasampson.
Umm, no. Maximum energy gain for a gravitational assist is a slingshot maneuver where you narrowly miss a head on collision with the planet, you will then be whipped around on a parabolic path and depart in the opposite direction with twice the planet's velocity added to your own. The "gravitational tugboat" maneuver you describe is great for minor boosts and course corrections, but is unlikely to be used for speed unless a slingshot maneuver is incompatible with reaching the desired destination. http://en.wikipedia.org/wiki/Gravity_assist [wikipedia.org]
As for a solar slingshot, yeah it's pretty pointless for in-system travel - it's hard to get close (not to mention survive the passing), and since it's basically the "stationary point" for the solar system you can't steal much speed from it, so once you reach your starting distance you'll have roughly* the same velocity as when you started with. Unless you just want to briefly go really fast for some reason, or are on an interstellar vessel seeking a gravity assist on your way to somewhere else in the galaxy, the sun is pretty useless for gravity boosts.
* You won't leave a solar slingshot with exactly the same velocity because the sun itself is orbiting the solar-system's barycenter, typically between about 1/2 and 1 solar-diameter from the sun's center and constantly moving as the orbiting of the outer planets shift the system's center of mass. So there will be some velocity transfer, just not enough to be actually useful.
A funny thing happened in the course of Lomas Brown trying to walk back his claim last week that he once intentionally missed a block in order to get his teammate Scott Mitchell injured: Brown says he has discovered that his memory is wrong, and the play on which he purposely missed a block is different than the play on which Mitchell suffered a season-ending injury.
That?s what Brown told Gregg Doyel of CBS: According to Brown, the former Lions left tackle who is now an ESPN commentator, ESPN went through its archives and found the play that ended Mitchell?s season, and it wasn?t the same play that Brown remembered.
After Brown?s boast about purposely getting Mitchell hurt became a hot topic in the NFL this week, someone posted a video on YouTube that appears to show the play that got Mitchell hurt in a loss to the Packers. That play does show Brown lining up at left tackle and turning to the inside, leaving Packers right defensive end Sean Jones alone to rush to the outside and get a free shot at Mitchell. But as the New York Times noted, there?s really no way to know whether Brown was supposed to block Jones on that play and intentionally let him go, or whether the Lions? pass protection on that play called for Brown to block to the inside.
Brown?s memory of the 1994 game is faulty. He described the Lions as being down 24-3 at the time he missed his block, but the score of that game was never 24-3. Based on the YouTube video, it appears that the score was actually 10-0 when Mitchell was hurt. And Brown?s description of the play suggests that he initially engaged Jones but then let him go, while the video shows Brown turning inside at the snap and never going near Jones.
In any event, whether Mitchell?s injury actually happened on a play on which Brown intentionally missed a block isn?t particularly important. Either (1) Brown tried to injure a teammate and succeeded, or (2) Brown tried to injure a teammate and failed but happened to get his wish because the teammate got injured on another play in the same game. Brown initially claimed option 1 but now claims option 2. Neither of those options reflects well on Brown.
The third option is that Brown fabricated a story about intentionally injuring a teammate because he thought that would be a swell way to get attention. That sounds ridiculous, but considering that Brown makes his living by appearing on ESPN First Take, a show that encourages its panelists to seek attention by making outrageous statements, it?s plausible.
If that?s what happened, and Brown has now discovered that the attention he generated is unwanted, claiming that he wasn?t actually responsible for Mitchell?s injury might be Brown?s way of attempting to minimize the damage to his reputation. But whatever Brown may say now, his reputation has been permanently tarnished.
New-home sales rose in November, recording their strongest pace in more than 2 years, another sign of improvement in the housing market.
The Census Bureau reported Thursday that sales of new homes rose to an annual rate of 377,000 in the month, up 4.4% from October, and up 15% from year-earlier levels. It was the highest rate of new-home sales since April 2010, when sales were inflated by a temporary $8,000 tax credit for home buyers.
A combination of near record low mortgage rates, lower unemployment and a drop in foreclosures means there are more buyers interested in purchasing, and fewer available homes. That in turn has lifted home prices.
Those supply-and-demand dynamics are especially true in the new-home market.
There was only a 4.7 month supply of new homes on the market in November, the same tight inventory as has been the case in four of the previous six months. The last time there was a tighter supply of new homes available was in October 2005, near the height of the housing bubble.
The tight supply has lifted the median price of a new home sold in November to $246,200, up 14.9% from the comparable price a year earlier.
Anika Khan, senior economist with Wells Fargo Securities, said the report was stronger than expected, especially for what is traditionally a slow month for home sales. She said new-home sales and construction are becoming a more important driver of overall economic growth, which is even more important with the economy facing other headwinds such as a cutback on business investment and consumer worries about the fiscal cliff.
?New-home sales is a good story and it will continue to be a good story,? she said.
New-home sales can be more important to the economy than sales of previously owned homes since they require purchase of other goods, such as appliances, and because of the construction jobs needed to build the homes.
The continued rebound in prices likely will be a positive for both purchases and construction in the year ahead. Higher prices give current homeowners an incentive to sell their homes and procure the down payment they need for their next home purchase. Potential home buyers, who may have been on the sidelines because of uncertainty about home prices, might also be lured into the market.
Dec. 27, 2012 ? Researchers have uncovered a novel role of BRCA1 in regulating the survival of skin stem cells.
Our DNA, which stores our genetic information, is constantly submitted to damage. If not properly repaired, DNA damage can lead to cell death, which may in turn lead to tissue exhaustion and aging, or induce mutations resulting in uncontrolled cell proliferation and cancer. Brca1 is a key gene that mediates DNA repair. Mutations in Brca1 lead to familial and sporadic breast and ovarian cancer in humans.
In this study published in Genes and Development, researchers led by C?dric Blanpain, MD/PhD, Professor at Universit? libre de Bruxelles (ULB) and WELBIO investigator, showed the critical role of Brca1 for the maintenance of hair follicle stem cells.
Peggy Sotiropoulou and colleagues showed that upon deletion of the breast cancer associated gene Brca1 in the epidermis, hair follicle cells show high levels of DNA damage and cell death, which induce hyperproliferation and finally exhaustion of hair follicle stem cells resulting in hair follicle degeneration. In contrast, the other types of stem cells located in the epidermis, which are forming the skin barrier and the sebaceous glands, are maintained and continue to function normally despite the absence of BRCA1, demonstrating the different requirement for BRCA1 in the distinct types of adult stem cells. "We were very surprised to see that distinct types of cells residing within the same tissue may exhibit such profoundly different responses to the deletion of the same, crucial gene for DNA repair gene" comments Peggy Sotiropoulou, the first author of this study.
This work is very important to understand the DNA repair mechanisms in different types of adult stem cells and at different stages of their activation. If other stem cells of the body also require BRCA1 for their survival, this result may potentially explain why Brca1 mutations in women lead preferentially to the development of only breast and ovarian cancers.
This work was supported by the FNRS, WELBIO, the program d'excellence CIBLES of Wallonia, a research grant from the Fondation Contre le Cancer, the Fondation ULB, the Fonds Yvonne Bo?l, and the Fonds Gaston Ithier, a starting grant of the European Research Council (ERC) and the EMBO Young Investigator Program.
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The above story is reprinted from materials provided by Libre de Bruxelles, Universit, via AlphaGalileo.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
Panagiota A Sotiropoulou, Andrea E. Karambelas, Maud Debaugnies, Aurelie Candi, Peter Bouwman, Virginie Moers, Tatiana Revenco, Ana Sofia Rocha, Kiyotoshi Sekiguchi, Jos Jonkers and Cedric Blanpain. BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny. Genes and Development, January 2013
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Most BabyBoomers would have to have been locked away in a sensory deprivation tank for the last fifty years to not have the immediate association that comes with the mention of the Red Ryder?BB Gun.?
The coveted item is the central prop in the classic, A Christmas Story, as the one childhood icon, the one modern morality play item, the one symbolic 1950?s product that many of us can appreciate, laugh about, or identify as central to our own lives, too.
The Red Ryder BB Gun comes in the adult-like official cardboard gun box that rifles and other more extreme firearms of the day were packed in.? It Is depicted on the front of that box in vivid, alluring colors and details, confirming it is the definitive, be-all and end-all must-haves.?
It encourages wish-fulfillment daydreams of heroism and hero-worshipand makes the most wonderful air-popping, the most satisfying whooshing sound when discharged.?
The Red Ryder BB Gun aptly (to the point of hilarity) described, or defined, by the narrator, expressing his childhood designs on the Red Ryder bb gun, more explicitly as the Daisy Red Ryder 200-Shot Carbine Action BB Air Rifle.??
Red Ryder BB Gun
The Red Ryder BB Gun was the one tool that would enable Ralphie to fend off escaped convicts with corny cat-burglar eye masks as well as the one item that would allow him to be the sole protector of his middle-class 1940?s nuclear family.
The Red Ryder BB Gun was the most threatening ?toy? a Baby Boomer Kid could ask for, over and over again, beg for, throw subtle or not-so-subtle tantrums over, and get one curt, mouth-shutting, dream-crushing response?the warning: ?You?ll shoot your eye out.??
And worse for you (but better for the millions who will witness your delightfully mocking and humorous retelling of the moment), you come damn near close to doing that very thing (what mother would surely consider the real eye destruction?if you didn?t lie and blame your broken glasses on a huge falling icicle).
A Christmas Story - Red Ryder BB Gun
But enrobing the almighty Red Ryder is a wealth of memories?of helping crazy Dad change a tire in a snow storm, of making terrifying mandatory visits to department store Santa, of being forced to wear Auntie?s hokey knitted sweater with the reindeer emblazoning the chest, and, subsequently and intermittently and for no reason whatsoever, being bullied by snot-nosed little creeps.?
And, after cajoling, attempting to manipulate, trying to drop hints, and working up the courage to get the one guy who will get it for you to listen to your rationale?the single, belated moment of actually getting the Red Ryder BB gun.?
Last month we held our 11th annual Investor Gathering. ?The day is a chance for our?partner community to come together to hear updates on our work here at Acumen. Sasha Dichter, Chief Innovation Officer at Acumen, gave a talk on investing in the spread of ideas. Sasha is focused on scaling Acumen?s impact by building on our core investing work to create the ecosystem of leaders the world needs to do this work; and investing in the spread of ideas by digging in to measure and understand the direct impact we are having through our investments and sharing these learnings with the world ? so we can all get smarter about what it really takes to tackle poverty at scale.
There are several important themes highlighted in the video, but in many ways it comes down to transparency and trust. The road ahead is tough, but this talk will give you a sense of where we need to go.
Changing the way the world tackles poverty will take all of us. Please consider a tax-deductible donation today!?100% of your gift goes directly to our investments. Click below to donate.
Happy holidays, and thank you for you support!
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WASHINGTON (AP) ? Supreme Court Justice Sonia Sotomayor on Wednesday denied a request to block part of the federal health care law that requires employee health-care plans to provide insurance coverage for the morning-after pill and similar emergency contraception pills.
Hobby Lobby Stores and a sister company, Mardel Inc., sued the government, claiming the mandate violates the religious beliefs of its owners.
In an opinion, Sotomayor said the stores fail to satisfy the demanding legal standard for blocking the requirement on an emergency basis. She said the companies may continue their challenge to the regulations in the lower courts.
Company officials say they must decide whether to violate their faith or face a daily $1.3 million fine beginning Jan. 1 if they ignore the law.
Attorneys for the government have said the drugs do not cause abortions and that the U.S. has a compelling interest in mandating insurance coverage for them.
In ruling against the companies last month, U.S. District Judge Joe Heaton said churches and other religious organizations have been granted constitutional protection from the birth-control provisions but that "Hobby Lobby and Mardel are not religious organizations."
Not that it would really be much of a worry since many people just do it regardless of the law, but UK residents set to receive any CDs or DVDs this Christmas will be able to do so safe in the knowledge that they can use a computer to back up their content without being?hunted?down by legislation, provided that the disc ripping that occurs is for personal use only.
After?a law amendment passed on Friday (21 December), the UK coalition?government has legally permitted consumers the right to burn content to their hard drives as ?digital copies?, with the law covering copied video content, music, and e-books, so long as it has been taken directly from the source?(as disc-to-file) and not used commercially.
While the rule also allows users to store their copied content onto a cloud storage service (seen in this case as similar to a hard drive, and rejecting rights holders? claims that this could create a form of illegal piracy),?it remains a crime to remove a??technical protection method? (TPM) from all copyrighted content, mainly designed to protect from copying in large quantities.
Government business secretary Vince Cable said of the changes: ?[The new legislation is] not only common sense but good business sense. Bringing the law into line with ordinary people?s reasonable expectations will boost respect for copyright, on which our creative industries rely. We feel we have struck the right balance between improving the way consumers benefit from copyright works they have legitimately paid for, boosting business opportunities and protecting the rights of creators.?
With a report on the matter summarising that the alterations create??a fair balance? between fair use for consumers?and?protecting the revenue streams of rights holders, will this trivial improvement be appreciated as a greater amount of freedom to use a paid-for disc as the user pleases?
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Egyptian women cut their hair to protest against the Islamist-oriented constitution during a demonstration in Tahrir Square, Cairo, Egypt, Tuesday, Dec. 25, 2012.
By Maria Golovnina, REUTERS
CAIRO - Egypt announced on Tuesday voters had approved overwhelmingly a constitution drafted by President Mohamed Morsi's Islamist allies, and the government imposed currency restrictions to cope with an economic crisis worsened by weeks of unrest.?
Final figures from the elections commission showed the constitution was adopted with 63.8 percent of the vote, giving Islamists their third straight victory at the polls since strongman Hosni Mubarak was toppled in a 2011 revolution.?
Morsi's Leftist, liberal, secularist and Christian opponents had taken to the streets to block what they argued was a move to ram through a charter that would dangerously mix politics and religion.?
The president argues that the new constitution offers sufficient protection for minorities, and adopting it quickly is necessary to end two years of turmoil and political uncertainty that has wrecked the economy.?
Hours before the vote result was announced, the authorities imposed a new ban on travelling in or out of the country with more than $10,000 in foreign currency, a move apparently intended to halt capital flight.?
Some Egyptians have begun withdrawing their savings from banks in fear of tougher restrictions.?
The "yes" vote paves the way for a parliamentary election in about two months, setting the stage for yet another electoral battle between surging Islamists and their fractious liberal and leftist opponents.?
The final result, announced by the election commission, matched --?to the last decimal place -- an earlier unofficial tally announced by Morsi's Muslim Brotherhood.?
The constitution was drawn up by a body largely made up of Morsi's Islamist allies. The results announcement was a disappointment for the opposition which had put pressure on the authorities to recount the result to reflect what they have described as major vote violations.?
"We have seriously investigated all the complaints," judge Samir Abu el-Matti of the Supreme Election Committee told a news conference. The final official turnout was 32.9 percent.?
Cairo, gripped by often violent protests in the run-up to the vote, appeared calm after the announcement and opposition groups have announced no plans for demonstrations to mark the result.?
"The results was so odd and no change in the percentage points shows that nothing was done to take our complaints into account," Khaled Dawood, an opposition spokesman, said.?
The referendum, held on December 15 and on December 22, has sown deep divisions in the Arab world's most populous nation but Morsi says enacting the new constitution quickly will bring stability and a chance to focus on fixing the economy.?
A growing sense of crisis has gripped Egypt's polarized society for weeks. Standard and Poor's cut Egypt's long-term credit rating on Monday.?
Hours ahead of the results announcement, Prime Minister Hisham Kandil told the nation of 83 million the government was committed to taking steps to heal the economy.?
"The main goals that the government is working towards now is plugging the budget deficit, and working on increasing growth to boost employment rates, curb inflation, and increase the competitiveness of Egyptian exports," he said.?
Nasser Nasser / AP file
An Egyptian election worker shows his colleagues an invalid ballot while counting ballots at the end of the second round of a referendum on a disputed constitution in this Saturday, Dec. 22, 2012 file photo.
CRISIS MODE?
The central bank said on Monday it would take steps to "safeguard" bank deposits, without giving any details. Rumors are rife of what sort of measures are planned.?
"I have been hearing that the central bank is going to take over all our bank deposits to pay wages for government employees given the current deteriorating economic situation," said Ayman Osama, father of two young children.?
He said he had taken out the equivalent of about $16,000 from his account this week and planned to withdraw more, adding that he had also told his wife to buy more gold jewellery.?
"I am not going to put any more money in the bank and neither will many of the people I know," he said.?
The referendum is the Islamists' third electoral victory since the fall of Mubarak, following parliamentary and presidential elections, representing a decisive shift in a country at the heart of the Arab world, where Morsi's Muslim Brotherhood was suppressed for generations by military rulers.?
However, secularist and liberal opposition members hope they can organize better in time for the next parliamentary vote.?
The opposition says the constitution fails to guarantee personal freedoms and rights for women and minorities. The government says the criticism is misplaced.?
Hossam El-Din Ali, a 35-year-old newspaper vendor in central Cairo, said he agreed the new constitution would help bring some political stability but like many others he feared the possible economic austerity measures lying ahead.?
"People don't want higher prices. People are upset about this," he said. "There is recession, things are not moving. But I am wishing for the best, God willing."?
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After?a law amendment passed on Friday (21 December), the UK coalition?government has legally permitted consumers the right to burn content to their hard drives as ?digital copies?, with the law covering copied video content, music, and e-books, so long as it has been taken directly from the source?(as disc-to-file) and not used commercially.
