Friday, September 21, 2012

Fears about global economy push dollar higher

NEW YORK (AP) ? The dollar rose against most other currencies Thursday after weak economic data from Asia and Europe pointed to more sluggishness in the global economy.

A private survey of manufacturers in China showed another decline in September. Japan, meanwhile, posted a $9.6 billion trade deficit in August as shipments to Europe and Asian countries fell.

In Europe, a closely watched survey suggested that the region is headed for a deepening recession. A purchasing managers' index for the 17 countries that use the euro fell to 45.9 in September from 46.3 in August, according to financial data company Markit.

Traders consider the dollar a safe haven, so it tends to rise when traders are worried about the economy.

The euro fell to $1.2967 in late trading Thursday from $1.3063 late Wednesday. The British pound fell to $1.6211 from $1.6230.

The dollar rose to 0.9330 Swiss franc from 0.9275 franc and to 97.66 Canadian cents from 97.42 Canadian cents.

The dollar also strengthened against currencies in Australia, New Zealand, Norway, South Korea and Hong Kong.

The dollar fell to 78.26 Japanese yen from 78.39 Japanese yen.

Source: http://news.yahoo.com/fears-global-economy-push-dollar-higher-160924994--finance.html

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'Half-match' bone marrow transplants wipe out sickle cell disease in selected patients

ScienceDaily (Sep. 20, 2012) ? In a preliminary clinical trial, investigators at Johns Hopkins have shown that even partially-matched bone marrow transplants can eliminate sickle cell disease in some patients, ridding them of painful and debilitating symptoms, and the need for a lifetime of pain medications and blood transfusions. The researchers say the use of such marrow could potentially help make bone marrow transplants accessible to a majority of sickle cell patients who need them.

After a median follow-up of two years, the transplants successfully eliminated sickle cell disease in 11 of 17 patients. Three were fully matched to their donors and eight received half-matched donor marrow. All 11 patients are free of painful sickle cell crises and 10 no longer have anemia. There were no deaths and no unexpected toxicities.

Six of the 11 patients (all half-matched) have stopped taking immunosuppressive drugs, although some still require narcotics for chronic pain because of sickle cell-related organ damage. Blood tests on the six patients show that their red cells are now completely derived from their donor's marrow.

Patients with severe sickle cell disease (SCD) face shortened life spans, intractable pain and eventual organ damage as a result of their disease, an inherited disorder caused by a mistake in the oxygen-carrying hemoglobin molecules in red blood cells. The flawed genetic code stiffens red cells, and shapes them into a pronged "sickle" that clump and stick into blood vessel walls, cutting off blood and oxygen to tissues and organs throughout the body.

SCD occurs in approximately one in 400 African Americans, and rarely in Caucasians. An estimated 100,000 people are currently living with sickle cell disease in the U.S.

Most patients die before age 50, and many suffer poor quality of life with frequent episodes of "off-the-charts" pain, and an increased risk for kidney failure, stroke, deep-vein thrombosis, and lung disease.

Treatments include blood transfusions and a drug, hydroxyurea. Many patients use narcotics to control severe pain and have repeat hospitalizations. Bone marrow transplants have been successful in curing some cases, but matching donors are rare and the procedure itself poses risk.

In the current study, 17 patients at the Johns Hopkins Hospital were offered bone marrow transplant options, including the use of half-matched donor marrow to try and replace their "sickled" blood cells with new, healthy ones. The transplants were successful in 11 of the patients, of whom eight were only half-matches. Results of the trial were published in the Sept. 6 early online edition of Blood.

"We're trying to reformat the blood system and give patients new blood cells to replace the diseased ones, much like you would replace a computer's circuitry with an entirely new hard drive," says Robert Brodsky, M.D., director of the Division of Hematology at Johns Hopkins and The Johns Hopkins Family Professor of Medicine and Oncology. "While bone marrow transplants have long been known to cure sickle cell disease, only a small percentage of patients have fully matched, eligible donors."

National registries often are of little help in finding donors for sickle cell patients, because most of those in need are African American and other minorities who are vastly underrepresented in registries, say the Johns Hopkins researchers.

To overcome the shortage of donors, investigators at Johns Hopkins developed techniques, recently tested in leukemia and lymphoma patients, to transplant with bone marrow that is half-identical or "haploidentical" to the patient's tissue type. Half-matched bone marrow can be obtained from parents, children and most siblings, and is extracted by needle from the hip bone.

For the study, the Johns Hopkins team screened 19 patients to find bone marrow donors with either half-identical or fully matched tissue. Each transplant candidate had experienced many severe pain crises, significant organ problems, or had failed hydroxyruea, the only drug known to curtail sickle cell symptoms. The team found donors for 17 of the 19 patients: 14 were half-identical and three were fully matched siblings. The youngest patient was 15; the oldest 46.

Before each transplant, sickle cell patients received a "conditioning" regimen of low-dose immunosuppression drugs, low toxicity chemotherapy, and low-dose total body irradiation. Brodsky says this gentler approach to pre-transplant therapy has made transplant possible for sickle cell patients whose tissues and organs have been ravaged by the disease.

After the transplant, all patients received high doses of the chemotherapy drug cyclophosphamide, which kills remaining blood cells, including diseased sickled cells, and preserves the donor's stem cells responsible for making new, healthy cells.

Of the 17 patients, six transplants were not successful; however, because of the reduced intensity of the conditioning regimen, all of these patients recovered their own blood cells.

There were no deaths, some infections, and only slight skin-related graft versus host disease symptoms in one patient, which cleared without therapy, the researchers reported. Some brain swelling occurred in three patients during the conditioning period and resolved without neurologic damage.

The Johns Hopkins doctors say that while the majority of patients in the trial had successful transplants, about less than half did not.

"Sickle cell disease patients undergo multiple blood transfusions throughout their lives and may have acquired antibodies against many different blood types, making it more difficult than usual to give patients donated bone marrow." says Javier Bola?os-Meade, M.D., associate professor of oncology at the Johns Hopkins Kimmel Cancer Center and principal investigator of the study.

Improving the rate of engraftment in haploidentical transplants for sickle cell disease remains a challenge, they say, but the researchers are looking for additional ways to overcome it, including increasing the number of stem cells transplanted and using other immunosuppressant drugs during the transplant.

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The above story is reprinted from materials provided by Johns Hopkins Medicine, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. J. Bolanos-Meade, E. J. Fuchs, L. Luznik, S. M. Lanzkron, C. J. Gamper, R. J. Jones, R. A. Brodsky. HLA-haploidentical bone marrow transplantation with post-transplant cyclophosphamide expands the donor pool for patients with sickle cell disease. Blood, 2012; DOI: 10.1182/blood-2012-07-438408

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/HDV_cgiAUPk/120920164654.htm

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Internet Explorer Fixes Security Issue to Protect Against Hackers

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Source: http://news.yahoo.com/internet-explorer-fixes-security-issue-protect-against-hackers-103242206.html

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Thursday, September 20, 2012

"Big Brother" gets early renewal for summer 2013

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Shop Health and Fitness

0

Exercise and exercise is a great way to feel better still achieve total wellness for our body. The physical and mental well-being of a person depends on him forever. One good thing about exercise is that it can help a person reduce the risk of getting heart disease or diabetes, even. It is also good to reduce the effects of depression and withdrawal of various different stressors. Taking benefits mental and physical fitness health are always well worth all the hard work. This will ensure that you are able to live a happier life and it is still in good shape. Now I have a big question for everyone. Do you want to live your life or simply to enjoy life and enjoy your life? The choice is yours. The discovery of different activities that will develop their current fitness level implies fitness health. Everyone has a different level of current fitness. It varies from one person to another. It can be brisk walking for 10 minutes. For some, it may be beneficial to run 1 mile. It can also be a hardcore weightlifting. So the point here is that you need to start your fitness level and should not be to assess where you want your fitness level health such as next year or the next two years. Be sure to set realistic goals that are difficult, but still achievable. Improve your physical health can have too many ways. You can select and participate in different activities that you will surely enjoy. This is a good way to stay healthy while achieving personal motivation aside. If you love and have fun playing basketball, then leave to participate in this sport can be twice a week. And if you do not like the gym, so do not require you to do so. Find other exercises that promote heart health, but it will keep you motivated and appreciated. It has long been our society, exerting considered something horrible that we must always stay away from him. And turning the whole situation into something positive to make a great help in achieving health fitness promising. Now, how many of us take some time to meet our own needs as usual? I guess not all of us. We have our families and the professionals who make us busy as a bee. Then you should take the time to find a value in itself at least once a week. Take this opportunity to do something, something new for you. You can simply soak in the bubble bath yourself or read a very interesting book. Also try to take a hobby you enjoy or you can learn new skills. Quality time that will certainly help you relax and relieve stress. It is of great importance to the physical condition of health. It has nothing to do with the exercise is. Proper way to eat also plays a vital role in physical health. You will feel very slow and irritable if you consume large amounts of carbohydrates and sugar. They provide a momentary impulse of energy, but not for long. Eating fruits and vegetables will help you keep your energy level throughout the day. This allows you to consume fewer calories, but you feel full throughout the day. Health Fitness is a key issue that most of us need to focus our interest. Because our influence both our physical and mental well-being. As a final point, it gives us the opportunity to be in better health than we can be.

I am not an expert just a few things that I always liked it when I need to lose a few pounds. One. Making the decision to be healthy and you want to lose weight 2. Choose a diet that is easier to maintain something that you can hold.

3. Make a shopping list and go to the grocery store.

4. Start Now. Do not wait, start at the next meal. It is never too late to start.

5. Eating smaller meals throughout the day to avoid being too hungry 6. Exercise and move your body at least 30 minutes per day. What to do: 1. Eat something before going to family reunions, and preferably something to satisfy you and proteins easier to say no to foods that should not be.

2. Say no to test a sweet flavored vodka cocktails and Club Soda I created this video with the YouTube editor Thanks for visiting my video channel. Please subscribe visit: Facebook-www. Facebook. Com-Beauty-Blogger/206841146022116 Twitter @ Ressa777 makeup brushes, Sigma'm an affiliate and you may be too. Www. Sigmabeauty. Blog Com: Vanitymine. Blogspot. Com FTC: Most products used in this video were purchased by me. (Www. Youtube. Com


About The Author

For more health articles visit http://thehealthbuffcorner.blogspot.com

Source: http://www.annmiami.com/shop-health-and-fitness-12/

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HTC Windows Phone 8X and 8S family portraits

HTC Windows Phone 8X and 8S family portraits

HTC introduced us to not one, but two Windows Phone 8 devices today. Sure, we've poked and prodded them but, before you get your chance to grope the 8S and 8X, we figured a proper introduction is order. So, meet the whole family in all their brightly colored glory!

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HTC Windows Phone 8X and 8S family portraits originally appeared on Engadget on Wed, 19 Sep 2012 11:15:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2012/09/19/htc-windows-phone-8x-and-8s-family-portraits/

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Wednesday, September 19, 2012

East vs. West: Stark Coast-to-Coast Culture Clash Revealed

When Facebook CEO Mark Zuckerberg showed up at a meeting with Wall Street investors in May wearing a hoodie, his sartorial choice sparked a flurry of headlines contrasting Silicon Valley's laid-back culture with the East Coast's insistence on formality.

Now, new research finds that this West Coast-East Coast culture clash isn't just media stereotyping. In fact, people living in the east coast city of Boston closely link their overall life satisfaction with how content they are with their own social status. In San Francisco, residents don't make the same connection, reflecting a more individualistic, free-to-be-me culture.

"Our ideas about who we are and how we should feel are shaped in quite dramatic ways by our local environment," said study researcher Victoria Plaut, a social and cultural psychologist at the University of California, Berkeley Law School. Broadly speaking, Plaut told LiveScience, the stereotypes are true: "If you examine the local world, you'll find that the East is more old and established, and the West is more new and free."

A tale of two cities

Plaut and her colleagues are interested in how interactions between a person's environment and their own individual characteristics affect their well-being. While your own personality, education, finances and relationships all make a difference in how happy you are, Plaut said, "they might matter in different ways in different places." [7 Things That Will Make You Happy]

The researchers wanted to go in-depth, so they picked two cities that are similar on many levels but differ in historical and cultural ways. Boston and San Francisco are both waterfront, politically liberal cities with similar economies and lots of well-educated residents, Plaut said. But while Puritans founded Boston in 1630, San Francisco didn't boom until the gold rush era of the 1840s, when thousands of hopeful miners flooded California, hoping to get rich quickly.

Even today, the makeup of the cities is different. About 60 percent of Bostonians are natives of Massachusetts, and only 16 percent of city residents are originally from other countries. In San Francisco, 38 percent of residents originally come from California. Nearly a third of San Franciscans are foreign-born.

Tradition vs. freedom

The attitude differences between the Boston metro area and the San Francisco Bay Area could be summed up in the marketing copy, or viewbooks, of the regions' prominent universities, Plaut and her colleagues wrote online Sept. 13 in the journal Personality and Social Psychology Bulletin. Stanford University in California opens its 2009 viewbook with the words, "The wind of freedom blows," and refers to "forward-looking, forward-thinking people" looking for "the freedom to be themselves."

Harvard University, on the other hand, opened its 2008 and 2009 viewbook by discussing the school's "tradition of excellence" since 1636 and talking up the community of students and faculty.

The researchers wanted to find out if this freedom versus tradition schism was widespread in each metro area. First, they surveyed an online sample of Bostonians and San Franciscans, asking them their own perceptions of social norms in their cities. They found Bostonians perceived the culture in Boston to be much more rigid than San Franciscans viewed Bay Area norms.

"Bostonians are more likely than San Franciscans to believe that there are clear expectations for how people should behave in their city," Plaut said. "Whereas San Franciscans are more likely than Bostonians to believe that in their areas people have the freedom to go their own way."

Next, the researchers analyzed the "cultural products" of each city ? newspaper headlines and the websites of hospitals and venture capital firms. (Health care and venture capital are major industries in both cities.) They found that the Boston Globe refers more often to communities and groups than the San Francisco Chronicle, which favors stories about innovation, creativity and notable individuals. While the Globe might lead with a headline like, "Church Struggles to Keep Its Voice," the Chronicle might go with "Wheelchair Athlete Sets High Goals."

Likewise, Boston venture capital firms were more likely to tout their reputation and experience, while San Francisco firms emphasized their pioneering spirit. Accel, a San Francisco firm, epitomized this attitude with marketing copy like, "We partner with entrepreneurs around the world who have unique, breakthrough ideas and the courage to be first."

Even local hospitals reflected their city attitude. Boston hospitals tried to lure patients with a focus on their facilities, skilled community of physicians and long histories. San Francisco hospitals were more likely to mention alternative medicine and individual patient empowerment.

Happiness differences

Next, Plaut and her colleagues looked beyond the marketing patter to the city residents themselves. They surveyed 3,485 Boston and San Francisco residents about their satisfaction with their finances, family, community, education and work, as well as their overall satisfaction with themselves. In Boston, overall satisfaction was contingent on satisfaction with all five of these factors, while in San Francisco, only work satisfaction was correlated with overall satisfaction.

In another survey, the researchers asked 403 riders of public transportation in Boston (the MBTA) and San Francisco (CalTrain) questions about things that made them happy(daily uplifts) and daily hassles. [7 Thoughts That Are Bad For You]

They found that Bostonians are at their happiest when relieved of daily hassles, especially those related to family and work relations ? again emphasizing the community-based nature of the city, Plaut said. In San Francisco, happiness was more closely tied to the number of everyday uplifting experiences a person had.

"The bottom line is that in Boston, people feel the social pressure more than in San Francisco," Plaut said.

The findings don't suggest that every Bostonian loves tradition and community while San Franciscans are all wild and free creative types, Plaut said. The differences are on a citywide scale, not an individual one. Nor does the study suggest that one city is happier than the other, just that residents of each city might find their happiness in different ways.

The trend is likely driven both by the cities' history and natives as well as by outsiders drawn by each town's reputation, Plaut said.

The findings are useful for understanding how cross-regional interactions ? like Zuckerberg's hoodie incident ? can go wrong, Plaut said. They may also matter to businesses trying to break into new markets or move employees from one city to another. Transferring to a city that doesn't share your values can be very disorienting, Plaut said.

"That can even cause unhappiness and anxiety. It can cause people to experience a lack of belongingness," she said. "Understanding the source of that disorientation is an important first step in addressing it."

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Source: http://news.yahoo.com/east-vs-west-stark-coast-coast-culture-clash-205233725.html

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