Thursday, November 10, 2011

Eddie Murphy Quits Job as Academy Awards Host (omg!)

Eddie Murphy Quits Job as Academy Awards Host

Next year's Oscar nominations have yet to be announced, but if its behind-the-scenes shakeups are any indication, it's going to be quite the show.

PHOTOS: Before they were Oscar nominees

On Wednesday, Eddie Murphy stepped down as host of the 84th Academy Awards, Us Weekly can confirm. The actor's announcement comes one day after Tower Heist director Brett Ratner resigned as producer of the program.

"First and foremost, I want to say that I completely understand and support each party's decision with regard to a change of producers for this year's Academy Awards ceremony," Murphy, 50, tells Us in a statement.

PHOTOS: Academy Awards style

"I was truly looking forward to being a part of the show that our production team and writers were just starting to develop, but I'm sure that the new production team and host will do an equally great job."

PHOTOS: Pregnant Oscar stars

Academy of Motion Picture Arts and Sciences President Tom Sherak respected Murphy's decision, telling Us: "I appreciate how Eddie feels about losing his creative partner, Brett Ratner, and we all wish him well."

Ratner, 42, recently came under fire for saying "rehearsal is for fags" while promoting Tower Heist. The controversial director also spoke openly about his sex life with actress Olivia Munn, who he claimed to "bang a few times" on the set of After the Sunset. (She denied sleeping with him to further her career.)

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Source: http://us.rd.yahoo.com/dailynews/rss/entertainment/*http%3A//us.rd.yahoo.com/dailynews/external/omg_rss/rss_omg_en/news_eddie_murphy_quits_job_academy_awards_host191034579/43548691/*http%3A//omg.yahoo.com/news/eddie-murphy-quits-job-academy-awards-host-191034579.html

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Hindsight haunts Joe Paterno in Penn State scandal: 'I wish I had done more'

Joe Paterno announced his retirement from Penn State football at the end of the season, saying the university's sex-abuse scandal was one of the 'great sorrows' of his life. The departure of Joe Paterno, a legendary coach, shows how deeply the story will hit Penn State.

The child abuse sex scandal at Penn State University is continuing to reverberate.

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Penn State?s famed football coach, Joe Paterno, has announced he will retire at the end of the season ? his 46th. Mr. Paterno, considered to be one of the nation?s premier football icons, now says he wishes he had done more once he learned that one of his former coaches, Jerry Sandusky, had been observed assaulting a 10-year old boy in the team showers.

There are also reports that the president of Penn State, Graham Spanier, will either resign or be fired shortly.

Even with both men gone, sports experts say Penn State and its reputation have been badly damaged. Before the scandal, Penn State was known as a ?clean? athletic program that had high academic standards and did not violate NCAA rules. The university could proudly point to itself as leading research institution.

?This is a stain that will take a long time to get over,? says David Carter, professor of sports business at the University of Southern California in Los Angeles. ?It will have an impact on recruiting, and fundraising.?

The scandal started to unfold after a grand jury indicted Mr. Sandusky, a defensive coach who worked with Paterno for 23 years, on charges of assaulting eight boys over a 15 year period. In addition, the grand jury indicted Athletic Director Tim Curley and another senior official, Gary Schultz, on charges of perjury. Neither Paterno or Mr. Spanier were charged. All of the men are disputing the allegations.

Paterno, announcing his retirement on Wednesday, said, ?This is a tragedy. It is one of the great sorrows of my life. With the benefit of hindsight, I wish I had done more."

In football circles, Paterno is mentioned in the same breath with other legendary coaches ? Alabama?s Bear Bryant, Eddie Robinson of Grambling, and Notre Dame?s Knute Rockne. He holds the record for the most wins in Division I football. But he has been criticized for not becoming more involved after a graduate student told him he had seen Sandusky and the 10-year-old boy in the locker room shower.

?If it had been immediately reported, at least they could say, 'As soon as we found out about it, we put the health and welfare of the child at the forefront,' ? says Robert Malekoff, chair of the sports studies department at Guilford College in Greensboro, N.C. ?That would have been a positive.?

Mr. Malekoff wonders if the university officials decided that the reputation of the coach and Penn State was more important than the well-being of the underage children.

?It?s always the cover-up that kills you,? he says.

He notes that in 1998, Penn State University police investigated a complaint from a mother that her son was being molested by Sandusky. After what was described in the indictment as a lengthy investigation, the case was dropped.

?But everyone of every importance must have known about it,? says Malekoff. ?So, in 2002, when another incident occurred, it just did not come out of nowhere,? he says. ?What I am saying is that now there was a pattern.?

He is not the only one who is surprised that Sandusky's alleged activities were not discovered earlier.

?What boggles my mind is that, for the years that Sandusky was at Penn State, weren?t there any discussions among the players about whether the coach was up to something?? wonders Patrick Rishe, an assistant professor of economics at Webster University in St. Louis.?

Of course, Penn State is not the only school where there has been a scandal. This year, Ohio State?s Jim Tressel lost his job after it was discovered players were accepting unauthorized gifts. This summer, North Carolina coach Butch Davis was fired after it was discovered there were NCAA rules violations. And, in the past there have been scandals at Southern Methodist University, the University of Miami, and the University of Washington.

?There are scandals all over,? says Mr. Rishe. ?But nothing like this scandal.?

Some coaches accept that they are held to high standards. In 2003, in an interview with The Dallas Morning News, University of Texas football coach Mack Brown said, ?We?re role models for kids. We get paid a lot of money to be role models for those kids.?

Paterno would almost certainly agree with that statement. Which is what makes the scandal so damaging.

?He is in the class of John Wooden, who transcended the sport and the university and became the face of the region,? says Mr. Carter.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/v-Yf8EHXL6A/Hindsight-haunts-Joe-Paterno-in-Penn-State-scandal-I-wish-I-had-done-more

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Wednesday, November 9, 2011

Michael Jackson House Contents Up For Sale

Auction items from rented home include bed on which Jackson died.
By Gil Kaufman

Michael Jackson's fans are notorious for their rabid worship of the late pop star. But will they pony up big bucks to own the bed on which their icon died? We will find out on December 17, when Julien's Auctions Gallery will auction off the contents of the rented Holmby Hills, California, home that Jackson was renting at the time of his death.

Though the announcement of the sale does not mention Jackson by name, it lists a variety of fine art and furnishings from the residence, including a gilded Louis XV headboard (est. $3,000/$4,000) and a $30,000 watercolor painting by Maurice Utrillo. An Associated Press story revealed that the sale of contents of 100 North Carolwood Drive will comprise items left behind by Jackson.

The singer passed away in the home on June 25, 2009, and on Monday his personal physician, Dr. Conrad Murray, was found guilty of one felony count of involuntary manslaughter in Jackson's death. Among the pieces of evidence brought up by prosecution witnesses attesting to Murray's medical incompetence was the fact that he gave Jackson CPR on a bed instead of a hard surface. The hundreds of items up for sale in the auction include the queen-size bed where Jackson slept.

In an ironic twist, just as Murray was getting news of the guilty verdict, reporters were being taken through the three-story home on a private tour in order to publicize the auction.

"We want to preserve the history of these items," said auctioneer Darren Julien of the contents, which include paintings and sculptures Jackson surrounded himself with in the rented home as he tuned up for his planned "This is It" comeback tour. The house, where Jackson lived with his three children from December 2008 until his death, is also separately up for sale.

One of the most-personal items on the block ($400) is a chalkboard that hung in the home's kitchen that features a note from the kids that reads, "I (heart) Daddy. SMILE, it's for free." A mirror on an antique armoire in Jackson's private bedroom featured a message the star wrote to himself that read, "TRAIN, perfection, March April. FULL OUT May," a reference to the grueling rehearsal schedule the 50-year-old was keeping up as he prepared for the string of concerts that were to begin in London in July 2009.

Reporters also saw a "medication room," the bedroom shown in evidence photos at Murray's trial, where fans can pick up upholstered chairs smudged with Jackson's makeup. An attorney for Jackson matriarch Katherine Jackson said that the family is aware of the auction and has made certain that the event does not use Michael's name or likeness to help sell the items; Jackson's name is not mentioned in the promotional materials for the auction.

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Source: http://www.mtv.com/news/articles/1674021/michael-jackson-house-content-auction.jhtml

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Tuesday, November 8, 2011

'Survivor' Winner Ethan Zohn Finishes New York Marathon

Ethan Zohn, who recently revealed his cancer has returned, was able to finish the New York Marathon on Sunday for the second year in a row. Despite his cancer recurrence, Zohn -- who began training for the marathon after he and girlfriend Jenna Morasca were eliminated from The Amazing Race -- finished the 26.2 miles in 4:20:46.

Source: http://www.ivillage.com/survivor-winner-ethan-zohn-finishes-new-york-marathon/1-a-400036?dst=iv%3AiVillage%3Asurvivor-winner-ethan-zohn-finishes-new-york-marathon-400036

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New study uncovers how brain cells degrade dangerous protein aggregates

New study uncovers how brain cells degrade dangerous protein aggregates [ Back to EurekAlert! ] Public release date: 7-Nov-2011
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Contact: RIKEN Global Relations Office
gro-pr@riken.jp
RIKEN

Researchers at the RIKEN Brain Science Institute (BSI) have discovered a key mechanism responsible for selectively degrading aggregates of ubiquitinated proteins from the cell. Their findings indicate that the capture and removal of such aggregates is mediated by the phosphorylation of a protein called p62, opening the door to new avenues for treating neurodegenerative diseases such as Huntington's disease and Alzheimer's disease.

One of the most important activities of a cell is the production of proteins, which play essential functions in everything from oxygen transport, to immune defense, to food digestion. Equally important to the cell's survival is how it deals with these proteins when they pass their expiry date: damaged or misfolded proteins have been associated with a range of debilitating conditions, including neurodegenerative diseases such as Alzheimer's disease.

In eukaryotic cells, the recycling of damaged or misformed proteins is governed by a small regulatory protein called ubiquitin in a process called "ubiquitination". By attaching itself to a protein, a ubiquitin molecule can tag the protein for destruction by proteasomes, large protein complexes that degrade and recycle unneeded proteins in the cell. This recycling of proteins by proteasomes is crucial to the maintenance of cellular homeostasis.

With their research, the BSI research group sought to shed light on one area where proteasome-based recycling falls short: protein complexes or aggregates, which proteasomes have trouble degrading. The group shows that this weakness is made up for by the phosphorylation of a protein called p62 at the serine 403 (S403) loci of its ubiquitin-associated (UBA) domain, which triggers a catabolic process called selective autophagy that degrades protein aggregates. It does this by forming a "sequestosome", a structure which sequesters polyubiquitinated protein aggregates in preparation for autophagy. (Figure 1)

###

Published in the journal Molecular Cell, the discovery of this mechanism opens the door to the development of new, more effective drugs for selectively degrading protein aggregates, promising applications in the treatment of a range of neurodegenerative diseases.



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


New study uncovers how brain cells degrade dangerous protein aggregates [ Back to EurekAlert! ] Public release date: 7-Nov-2011
[ | E-mail | Share Share ]

Contact: RIKEN Global Relations Office
gro-pr@riken.jp
RIKEN

Researchers at the RIKEN Brain Science Institute (BSI) have discovered a key mechanism responsible for selectively degrading aggregates of ubiquitinated proteins from the cell. Their findings indicate that the capture and removal of such aggregates is mediated by the phosphorylation of a protein called p62, opening the door to new avenues for treating neurodegenerative diseases such as Huntington's disease and Alzheimer's disease.

One of the most important activities of a cell is the production of proteins, which play essential functions in everything from oxygen transport, to immune defense, to food digestion. Equally important to the cell's survival is how it deals with these proteins when they pass their expiry date: damaged or misfolded proteins have been associated with a range of debilitating conditions, including neurodegenerative diseases such as Alzheimer's disease.

In eukaryotic cells, the recycling of damaged or misformed proteins is governed by a small regulatory protein called ubiquitin in a process called "ubiquitination". By attaching itself to a protein, a ubiquitin molecule can tag the protein for destruction by proteasomes, large protein complexes that degrade and recycle unneeded proteins in the cell. This recycling of proteins by proteasomes is crucial to the maintenance of cellular homeostasis.

With their research, the BSI research group sought to shed light on one area where proteasome-based recycling falls short: protein complexes or aggregates, which proteasomes have trouble degrading. The group shows that this weakness is made up for by the phosphorylation of a protein called p62 at the serine 403 (S403) loci of its ubiquitin-associated (UBA) domain, which triggers a catabolic process called selective autophagy that degrades protein aggregates. It does this by forming a "sequestosome", a structure which sequesters polyubiquitinated protein aggregates in preparation for autophagy. (Figure 1)

###

Published in the journal Molecular Cell, the discovery of this mechanism opens the door to the development of new, more effective drugs for selectively degrading protein aggregates, promising applications in the treatment of a range of neurodegenerative diseases.



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2011-11/r-nsu110711.php

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Markets abandoning hopes for lasting euro zone solution (Reuters)

NEW YORK (Reuters) ? After another week of confusion and turmoil in Europe, investors are ditching whatever hopes they once had for a conclusive solution to the debt crisis.

That may foreshadow a gloomy holiday season in markets, especially if wary investors opt to reduce risk in their portfolios and take refuge in U.S. Treasuries and the dollar.

Just weeks after it seemed leaders had drafted a master plan to solve the crisis, doubts rose about whether Greece would back a 130 billion-euro bailout.

And as politicians in Athens struggled to form a consensus government, Italian bond yields spiked to a euro-era high of 6.4 percent, raising fears that the country may soon need to follow Greece and others in seeking an emergency bailout.

"At the end of the day, it does seem like a grand plan is elusive at best," said David Ader, head of government bond strategy at CRT Capital Group in Stamford, Connecticut.

"We've seen one European bank and one U.S. brokerage fail. We know there are strains for French banks. We're wondering how long it will be before Greek default worries spread to Italy and Spain," he said. "In a situation like that, money managers are going to decide to simply take their risk down."

Investors are betting the market will see evidence of that as soon as this week, as flight-to-safety flows help boost U.S. Treasury debt, lift the dollar against the euro and weigh on stock markets around the world.

The biggest fear is that a disorderly default in Greece or elsewhere would ripple across the global financial market the same way the Lehman Brothers collapse did in 2008. That, investors fear, would probably be enough to plunge the global economy into recession.

"This is going to be pretty negative news for risk markets," said Jack Ablin, chief investment officer at Harris Private Bank in Chicago. "We are going to see a continued flight-to-quality tomorrow."

Benchmark U.S. 10-year note yields dropped more than 29 basis points in the past week and a half as worries about Europe overshadowed signs of economic improvement in America.

FADING RISK RALLIES

Ashraf Laidi, CEO of Intermarket Strategy in London, said he expected the euro to struggle again this week after losing nearly 3 percent against the dollar last week. By year end, he said it could fall below $1.30. It was around $1.38 Friday.

"This past week really raised some tricky questions," he said. "For the first time I can remember, the possibility that Greece really could leave the euro zone was being talked about in cafes and bars as well as on trading desks."

If Greece can cobble together a new unity government that backs the EU rescue plan, that might, "at least for a while, be a market-stabilizing factor," said Citigroup currency strategist Greg Anderson.

Prime Minister George Papandreou suggested Sunday he was ready to pass the baton.

But that is not likely to cheer investors much, meaning any rally in stocks or the euro will be shallow and brief.

"These 24-hour risk-on rallies, I don't know how much longer people are going to be willing to do that," said Ader. "Sell-offs are getting deeper because the rallies are only short-covering moves. People are not getting long and putting on bets that everything is suddenly OK."

FROM GREECE TO ITALY

Alan Ruskin, head of G10 currency strategy at Deutsche Bank in New York, said the focus is likely to shift from Greece to Italy fairly quickly in the weeks ahead, and that should mean more market volatility and unwillingness to take on risk.

Italy's debt-to-output ratio stands at 120 percent, second only to Greece in the 17-country euro zone, and its borrowing costs are rising.

Prime Minister Silvio Berlusconi recently refused a loan offer by the International Monetary Fund and his government may be on the verge of collapse.

"Berlusconi says Italians are not feeling the crisis but that's because the European Central Bank has been providing high levels of liquidity at low interest rates and buying Italian bonds," Ruskin said. "That begs the question, should the ECB stop that to show them this is really a crisis?"

"I have to believe a lot of investors like me are thinking this could be the start of Italy week," said James Paulsen, chief investment strategist at Wells Capital Management in Minneapolis. "Italy is going to rapidly rise on investor radar screens and may be the bigger story."

(Additional reporting by Richard Leong, Daniel Bases, Karen Brettell and Julie Haviv in New York; editing by Bernard Orr)

Source: http://us.rd.yahoo.com/dailynews/rss/eurobiz/*http%3A//news.yahoo.com/s/nm/20111106/bs_nm/us_markets_europe_turmoil

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Monday, November 7, 2011

Wall Street Week Ahead: Coping with Europe's chaos (Reuters)

NEW YORK (Reuters) ? U.S. stock investors have had to take their own self-help course on living with uncertainty due to Europe's crisis, and they may need to draw on that next week because it's never clear when the next upheaval will come.

Sentiment will probably receive a boost after Greek Prime Minister George Papandreou won a parliamentary confidence vote early Saturday.

The vote helped the cash-strapped country avoid snap elections that would have destroyed its bailout deal and turned up the flames on the euro zone's economic crisis, though risks to the global financial system remain.

Greece is still in turmoil. Papandreou signaled he would still stand down, calling for a new coalition to ram the bailout deal through parliament and keep the nation from going bankrupt.

Other challenges haven't gone away, such as keeping countries like Italy from going the way of Greece. So, while investors may cheer the Greece vote, two years of crisis have taught them to be vigilant of new risks emerging from Europe's debt debacle.

"It takes away the risk of a referendum or renegotiating new terms. Net-net it's a 'risk-on' event," Thomas Roth, executive director of U.S. government bond trading at Mitsubishi UFJ Securities USA, in New York, said about the Greece vote.

"How much you can rally on this? It may be temporary at best. You have still have a lot of risks like Italy. We just don't know ... All in all, it's a slight positive for stocks and a slight negative for bonds."

Though investors are cautious, stocks may be able to keep in place the recent upward trend as more evidence suggests the U.S. economy is progressing despite Europe's woes.

Friday's U.S. monthly jobs report suggested some improvement in October, even though the headline payroll numbers appeared weaker than expected.

"What I'm seeing at the moment is that investors are getting more reassured with the picture that the U.S. may actually do OK despite the troubles in Europe," said Natalie Trunow, chief investment officer of equities at Calvert Investment Management in Bethesda, Maryland, which manages about $13 billion.

"The more recent datapoints on the U.S. economy and earnings profiles are supporting that assertion," she said.

Stocks ended with losses for the week.

But on Monday, the benchmark Standard & Poor's 500 index (.SPX) posted an 11 percent gain for October, its best monthly percentage rise since December 1991.

With results in from some 433 of the S&P 500 companies, 70 percent have beaten forecasts on third-quarter earnings, defying views that growth would be hit by the problems in Europe and a slower economy in China.

Analysts have said earnings growth has helped to support the market and has taken some of the focus away from Europe, even if just momentarily.

More reports are expected next week, including several retailers like Macy's (M.N), whose results could shed some light on how the holiday shopping season may go.

"If there isn't a lot of resolution on the European front, some of the big company earnings could be market movers. There are a lot of positives about the U.S. economy, and strong earnings are one of them," said Rob Morgan, chief investment strategist at Fulcrum Securities in Philadelphia.

EUROPE STILL CAUSE FOR VOLATILITY

Still, strategists see plenty of volatility ahead, making any big moves hard for short-term investors.

The CBOE Volatility index (.VIX) fell 1.1 percent to close at 30.16 on Friday, but is well above levels from just last summer. It was trading near 20 in early August.

On the week, the VIX rose 22.9 percent following wide market swings in four of five trading sessions.

"It's all Europe all the time unless we hear otherwise. The underlying tone and theme in the market will be set in Europe until or unless there's some finality to the debt crisis," said Steve Sosnick, equity risk manager at Timber Hill/Interactive Brokers Group in Greenwich, Connecticut.

Similarly, options strategist Frederic Ruffy of WhatsTrading.com, a website headquartered in New York, said: "Investors wait to see whether Greece will implement tough and unpopular austerity measures to avoid a messy debt default."

By taking a longer-term approach, though, some investors have been able to see the current situation as a buying opportunity, analysts said.

Stock valuations are cheap, so if earnings hold up, investors are likely to be better positioned in stocks than in bonds or cash, they said.

The S&P 500 forward price-to-earnings ratio is now at 12, its lowest in years.

"Savvy investors are using the dips to put some money to work, but this is a very difficult market if you're a short-term trader," said Fred Dickson, chief market strategist at The Davidson Cos. in Lake Oswego, Oregon.

Besides earnings, U.S. economic news has helped keep worries about another recession at bay.

Non-farm payrolls rose a tepid 80,000 in October, below economists' expectations. But employers added 102,000 more jobs than previously estimated in August and September.

And the U.S. unemployment rate slipped to 9 percent. It had been stuck at 9.1 percent for three straight months.

Among key economic reports next week are the government's data on the Consumer Price Index and Producer Price Index.

(Reporting by Caroline Valetkevitch; Additional reporting by Ryan Vlastelica, Doris Frankel and Edward Krudy; Editing by Jan Paschal and Burton Frierson)

Source: http://us.rd.yahoo.com/dailynews/rss/world/*http%3A//news.yahoo.com/s/nm/20111105/bs_nm/us_usa_stocks_weekahead

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